jQueryjQuery has a comprehensive set of documentation - everything from specific methods with code samples to a step-by-step Tutorial.
Most of the methods that you might be interested in would be in the jQuery Base - but feel free to look at the other modules for the applicable information.
If you're looking for a good place to start, I'd recommend taking a look at the Tutorial, it gives you a number of popular scenarious, and walks you through the process of using jQuery.
If you're planning on using jQuery with Prototype, make sure you read this before beginning.
If you're wondering why jQuery looks so different, you might be interested in what we call Chainable Methods.
Also, if you'd like to extend jQuery to add your own methods, you'd be interested in developing a Plugin.