CSS preprocessors like Sass and LESS add powerful features to CSS like variables, nesting, mixins and more. They must be compiled into plain CSS for use on websites. Both can be compiled server-side or locally. Sass is generally considered more full-featured thanks to libraries like Compass. It has a larger user and developer community compared to LESS. The document recommends using a preprocessor like Sass for development only, compiling CSS locally, and sharing code through a team library.