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INTRODUCTORY
BIOSTATISTICS
INTRODUCTORY
BIOSTATISTICS
CHAP T. LE
Distinguished Professor of Biostatistics
and Director of Biostatistics
Comprehensive Cancer Center
University of Minnesota
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ISBN 0-471-41816-1
10 9 8 7 6 5 4 3 2 1
To my wife, Minhha, and my daughters, Mina and Jenna
with love
CONTENTS
Preface xiii
Bibliography 483
Appendices 489
Answers to Selected Exercises 499
Index 531
PREFACE
And yet, this artificiality being once conceded, how beautiful is the
structure! How fine the material, and how symmetrically it is put
together! Sometimes, perhaps, the narrative lags a little; sometimes
the descriptions, like those of Cedric’s hall or Athelstane’s castle, are
longer than the impatience of the reader cares to tolerate. Yet the
great scenes of the drama, how vividly do all these stand forth in our
memory! How splendid the stage setting and how well arranged the
incidents!
The story opens quietly. Gurth, the swineherd, and Wamba, the
jester of Cedric the Saxon, are driving home a herd of swine, when
they are overtaken by Prior Aymer and the Templar Brian de Bois-
Guilbert with their train. Then follows the supper scene at
Rotherwood, the residence of Cedric, where Ivanhoe, disguised as a
wandering palmer, returned from Palestine, visits his father’s home,
answers the boasting taunts of the Templar, saves the poor Jew,
Isaac of York, and is supplied with armor for the coming tourney.
“Know, bright lily of the vale of Baca, that thy father is already in
the hands of a powerful alchemist, who knows how to convert
into gold and silver even the rusty bars of a dungeon grate. The
venerable Isaac is subjected to an alembic, which will distill from
him all he holds dear, without any assistance from my requests or
thy entreaty. Thy ransom must be paid by love and beauty, and in
no other coin will I accept it.”
And yet, in spite of such defects, the heroism displayed by Rebecca
in this particular scene has made it one of the most attractive in the
entire story. Rebecca is indeed one of the noblest characters in
fiction, and the portrait is natural and human, as well as heroic.
Although she was delivered from the stake by her champion, the
story ends sadly for her, since the knight whom she loves has
become the husband of Rowena. Scott tells us in his preface that he
has been censured for this, but he adds, with admirable taste, that
he thinks that a character of a highly virtuous and lofty stamp is
degraded rather than exalted by an attempt to reward virtue with
temporal prosperity.
That same night Don Rodrigo has sent his bravoes to abduct Lucia.
They steal into the house, but find it empty, and are suddenly
startled by the ringing of the bell, which has followed the outcry of
Don Abbondio. “Each of the villains seems to hear in these peals his
name, surname, and nickname,” and they flee in consternation,
while the betrothed betake themselves to the convent of Father
Cristoforo, at Pescarenico; and the tumult aroused in the village by
these events, admirably pictured by the novelist, at length subsides.
Renzo reaches Milan at the time of the breaking out of the bread
riots, due to the prevailing famine. The looting and destruction of
one of the bake-houses is vividly described, and also the attack upon
the superintendent of provisions. Renzo can not keep out of these
exciting scenes, and becomes quite a hero, making a speech to the
crowd, innocent enough in purpose, but easily construed into
sedition by a secret agent of the government who hears it, attaches
himself to Renzo, acts as his guide to an inn in the neighborhood,
where the innocent young man unlawfully refuses to give his name
to the innkeeper, but unwittingly reveals it to his guide; then goes to
bed intoxicated, is arrested next morning, escapes from the officers
of justice in the midst of the crowd, flees from the city, and does not
stop until he has quit the duchy of Milan, crossed the Adda, and
taken refuge with his cousin Bortolo in the Bergamascan territory—
all of which is followed by proceedings declaring him a dangerous
outlaw,—luckily, however, after he is well out of reach.
When the morning breaks after a night of this remorse, he hears the
distant chiming of bells; learns of the festival of the people in the
neighborhood who were going to meet their bishop, Cardinal
Federigo Borromeo, and, by a sudden impulse, he too determines to
go and present himself to the cardinal. The history of this great
prelate, a saintly man, is given in detail—his works of charity, his
writings, his efforts in the cause of education. The Unnamed is
welcomed by the Cardinal with joy and genuine tenderness, and the
details of a religious conversion, often repulsive to an unsympathetic
reader, here become, through the author’s skill, both natural and
attractive.
“Signor Curate, why did you not unite in marriage this Lucia with
her bethrothed husband?”....
“‘And why then, I might ask you, did you undertake an office
which binds upon you a continual warfare with the passions of the
world?... Ah, if for so many years of pastoral labors you have
loved your flock (and how could you not love them?)—if you have
placed in them your affections, your cares, your happiness,
courage ought not to fail you in the moment of need; love is
intrepid.’”
The unhappy man now finds that he has been betrayed by Griso, the
chief of his bravoes, who, under pretense of bringing the doctor, has
introduced into the room the horrible monatti, whose duty it is to
drag away the dead to their graves and the sick to the Lazaretto.
They plunder the stricken man of his treasures before his eyes, and
then carry him away.
“The monatto laid his right hand on his heart; and then zealously,
and almost obsequiously, rather from the new feeling by which he
was, as it were, subdued, than on account of the unlooked-for
reward, hastened to make a little room on the car for the infant
dead. The lady, giving it a kiss on the forehead, laid it on the spot
prepared for it, as upon a bed, arranged it there, covering it with
a pure white linen cloth, and pronounced the parting words:
‘Farewell, Cecilia! rest in peace! This evening we, too, will join
you, to rest together forever. In the meanwhile, pray for us; for I
will pray for you and the others.’ Then, turning again to the
monatto, ‘You,’ said she, ‘when you pass this way in the evening,
may come to fetch me too, and not me only.’
Renzo learns that Lucia has been taken to the Lazaretto, and he
proceeds thither. The scenes in that dreadful abode of suffering are
described in detail. Here he meets Father Cristoforo, who in tending
the sick is already falling a victim.
Renzo seeks Lucia in vain amid the procession of the few persons
who were going forth cured from the Lazaretto, but he finds her at
last, convalescent in one of the little huts in the woman’s quarters. A
very characteristic conversation ensued between the lovers in regard
to the binding nature of her vow, which Renzo naturally disputes,
and calls Father Cristoforo to remonstrate and interpose. The good
father consolingly tells Lucia that she had no right to offer to the
Lord the will of another to whom she was already pledged; and by
virtue of the authority of the church he absolves her from her vow.
It is not long until the lovers, restored to their former happiness,
leave the Lazaretto; and the book concludes with the consummation
of their wishes—their marriage, and a happy wedded life.
A great deal of quiet satire pervades the story. Take, for instance,
the following, in the description of Lecco, at the very opening of the
book:
“those prudent persons who shrink back with alarm from the
extreme of virtue as well as vice, are forever proclaiming that
perfection lies in the medium between the two, and fix that
medium exactly at the point which they have reached, and where
they find themselves very much at their ease.”
“It was well for Lucia that she was not the only one to whom
Donna Prassede had to do good.... Besides the rest of the family,
all of whom were persons more or less needing amendment and
guidance—besides all the other occasions which offered
themselves to her, or she contrived to find, of extending the same
kind offices, of her own free will, to many to whom she was under
no obligations; she had also five daughters, none of whom were
at home, but who gave her much more to think about than if they
had been. Three of these were nuns, two were married; hence
Donna Prassede naturally found herself with three monasteries,
and two houses to superintend; a vast and complicated
undertaking, and the more arduous, because two husbands,
backed by fathers, mothers, and brothers; three abbesses,
supported by other dignitaries, and by many nuns, would not
accept her superintendence. It was a complete warfare, alias five
warfares, concealed, and even courteous, up to a certain point,
but ever active, ever vigilant. There was in every one of these
places a continued watchfulness to avoid her solicitude, to close
the door against her counsels, to elude her inquiries, and to keep
her in the dark, as far as possible, on every undertaking. We do
not mention the resistance, the difficulties she encountered in the
management of other still more extraneous affairs; it is well
known that one must generally do good to men by force.”
The story, like some other of the greatest works of fiction—like Don
Quixote, Les Misérables, nay, like Henry Esmond itself, is somewhat
too prolix. The long historical citations, the extracts from the edicts
and proclamations of the time, look as if the author considered it
necessary to prove his story rather than to let it prove itself. That
Renzo and Lucia should leave Father Cristoforo to die alone is, to my
mind, the most serious blemish in the book; but in spite of these
shortcomings, “The Betrothed” is entitled to one of the first places in
the front rank of the masterpieces of fiction.
EUGENIE GRANDET
HONORÉ DE BALZAC
It is not quite fair to Balzac to judge him by any one of the stories in
his encyclopædic “Comedie Humaine.” The countless varieties of life
and character which he portrays show the author’s versatility and
power, and have perhaps a value from their very number which can
not be adequately treated when we consider only a single specimen
of his work. Many of his characters, it is true, are grotesques; some
are absolute deformities; others are hard to understand by any but a
Frenchman,—French human nature, as it seems to me, being a little
different from human nature elsewhere; but there is one great work
of his which, although it is not without its morbid side, must appeal
to the common consciousness of all mankind, and bring to every
human heart the conviction of its spiritual truth. “Eugenie Grandet”
is a novel of this universal kind of excellence.
This is a story, the like of which has happened many a time in actual
life, but the cold skeleton of the tale as given above conveys not the
slightest idea of the warm flesh and blood with which it is invested.
The description of the old street and the dreary house and its
furniture is a literary jewel. The account of the way in which Grandet
accumulates his fortune, and of the neighborhood rumors regarding
his wealth, stirs our own acquisitiveness as we read it, and shows
him to be a very natural and almost inevitable sort of miser. He is
moreover a man of commanding ability, who extorts respect even
though he inspires abhorrence. The details of his habits, his
economies, and his schemes, as well as his personal appearance, are
admirably given. Equally lifelike are the descriptions of big Nanon,
the devoted house-servant, starved and overtasked, yet always
grateful to the master who took her when none others would; of the
wife, submissive, sensitive, magnanimous, and uncomplaining; and
of Eugenie, a girl who has grown up in perfect innocence of the
world, pure, beautiful, and of a generous and noble spirit. All these
are the subjects of an odious domestic tyranny on the part of
“Goodman Grandet,” the particulars of which are set forth with
powerful fidelity.
Charles is a rather uninteresting young dandy, who comes arrayed
for conquest. It is not unnatural that an artless girl like Eugenie
should fall in love with him, and her devices to procure him such
luxuries as a cake, a wax candle, and sugar for his coffee, add to the
charm of their simple love-making. The sympathy of the two women
in his sorrow contrasts sharply with the sordid calculations of the
miser, and the scene where Eugenie learns his needs by furtively
reading two of his letters (for even her good qualities are decidedly
of the French type) and then brings him her little store of gold, and
when he hesitates, begs him on her knees to take it—this scene is
very effective, as is also her despairing cry, after he departs, “O
mother, mother, if I had God’s power for one moment!”
But the more tragic parts of this simple drama are near its close,—
the stormy scene when Grandet learns that Eugenie has given
Charles her money, her imprisonment in a room of the old house,
her mother’s illness and patient death, and, ghastliest of all, the last
hours of the miser:
“So long as he could open his eyes, where the last sparks of life
seemed to linger, they used to turn at once to the door of the
room where all his treasures lay, and he would say to his
daughter, in tones that seemed to thrill with a panic of fear:
“‘Yes, father.’
“Then Eugenie used to spread out the louis on a table before him,
and he would sit for whole hours with his eyes fixed on the louis
in an unseeing stare, like that of a child who begins to see for the
first time; and sometimes a weak infantine smile, painful to see,
would steal across his features.
“‘That warms me!’ he muttered more than once, and his face
expressed a perfect content.
“When the curé came to administer the sacrament, all the life
seemed to have died out of the miser’s eyes, but they lit up for
the first time for many hours at the sight of the silver crucifix, the
candlesticks, and holy water vessel, all of silver; he fixed his gaze
on the precious metal, and the wen on his face twitched for the
last time.
“As the priest held the gilded crucifix above him that the image of
Christ might be laid to his lips, he made a frightful effort to clutch
it—a last effort which cost him his life. He called Eugenie, who
saw nothing; she was kneeling beside him, bathing in tears the
hand that was growing cold already. ‘Give me your blessing,
father,’ she entreated. ‘Be very careful!’ the last words came from
him; ‘one day you will render an account to me of everything here
below.’ Which utterance clearly shows that a miser should adopt
Christianity as his religion.”
Then follows the long waiting of Eugenie; the dastardly letter sent
by Charles after his return; the noble dignity with which she releases
him and pays his father’s creditors to preserve the honor of one who
is quite careless of it himself, and then resigns herself to her
hopeless destiny.
As for the characters, they are of the simplest type. The dashing
devil-may-care soldier and adventurer, the deep drinker, the heavy
player, the man who with equal gayety defies the bullets of the
enemy and the commonest precepts of morality, has here his
apotheosis. Perhaps the hero of the book even more than
D’Artagnan himself is Athos, the chief of the three musketeers, who,
having made an unfortunate marriage in his youth, has forsaken his
name and station and embarked upon a life of mere adventure. We
love him and admire him, and yet it is hard to tell why upon any
logical or ethical principles we should do either. Yet when he gets
very drunk, or when he hangs his wife because he finds that she
bears upon her shoulder the mark of a criminal conviction, we feel
that he has done in each case exactly the right thing. Generally a
novelist seeks by contrasting his hero with more commonplace
characters to set him off in relief, but in this novel almost everybody
is a hero, and all are equally and superlatively great and admirable,
except perhaps the poor woman who has been hanged and comes
to life again and engages in divers diabolical plots against the rest of
the world.
JANE EYRE
CHARLOTTE BRONTE
“Jane Eyre” is a book which impresses the reader with its power,—I
might say its masculine power, were it not for the fact that the
author gives us at every turn the woman’s point of view.
Jane Eyre now flees from Thornfield, concealing all traces of her
whereabouts. She wanders amid incredible hardships and
destitution, and at last finds shelter at Moor House, the home of St.
John Rivers and his two sisters, who are afterwards discovered to be
her relatives, and with whom she divides a legacy which she
receives from a deceased uncle. St. John is a country clergyman of
high character, full of zeal, ambition, and fanaticism, and determined
to devote his life to missionary service in India. He seeks her hand,
but she realizes that it is not from love but to make her his fellow
laborer in the work of the Gospel. He has sought to inspire her with
his own enthusiasm, and she is on the point of yielding, when she
seems to hear the voice of Rochester calling to her in pain and
anguish. She returns to Thornfield, and finds that the Hall has been
consumed in a conflagration kindled by the maniac, and that
Rochester, who had sought in vain to save the life of the wretched
creature, has been himself rescued, blind and a cripple, from the
ruins. She seeks him and becomes his wife.
But the bare recital of these leading events gives very little idea of
the characters in this somber and tragic tale, or the feelings which
control their actions. The book must be read through to be
understood. From the very beginning the author strikes a resounding
chord in human nature. Brutality to children stirs us to fury, and no
one, not even Dickens or Victor Hugo, has painted this form of
tyranny in livelier colors than Charlotte Brontë. The conduct of Mrs.
Reed and of Rev. Mr. Brocklehurst, the sanctified and inhuman
director of Lowood school, arouses our hot resentment.
Some days afterwards, while the author was leaning upon the
parapet of the quay at Cordova, Carmen, a young gipsy girl of a
strange and savage beauty, comes and sits near him. After some
conversation he accompanies her to her residence to have his
fortune told. Suddenly the door opens, and Navarro, in a very bad
humor, enters the room. A quarrel ensues between him and Carmen
in the gipsy language, and it appears from the gestures that the
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